Emerging neuroprotective effects of N-palmitoylethanolamide besides its significant antinociceptive effects.

PEA attenuates chemotherapy-induced neuropathies by attenuating endoneueral edema in myelinated nerve fibers [2]. Similarly, PEA improves distal motor latency in individuals with carpal tunnel syndrome [3]. Similar benefits have been noticed in pudendal neuralgias [4]. PEA also exerts beneficial effects in patients with multiple sclerosis by ameliorating neuropathic pain [5]. PEA also increases the latency between tonic clonic seizures and thus exhibits anti-epileptic activity [6].